Contraindications to Pepto-Bismol that Wegovy users should be aware of include: Salicylate hypersensitivity (including aspirin allergy) Under 16 years of age (risk of Reye's syndrome) Bleeding disorders Severe renal impairment Pregnancy and breastfeeding Important interactions include: Anticoagulants (especially warfarin) Other salicylates and NSAIDs Methotrexate Some antibiotics (tetracyclines, quinolones) reduced absorption Recommended approach : Use Pepto-Bismol only for mild, self-limiting symptoms during the initial adjustment period
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Improved insulin sensitivity is closely linked to favorable changes in body composition, such as decreased BMI and waist circumference, which are critical for PCOS patients who often present with obesity
Other common causes of cold sensitivity should also be considered, including iron-deficiency anaemia and vitamin B12 deficiency (particularly relevant for patients also taking metformin, which can reduce B12 absorption)